The Tian Research Group

Welcome to the PChem-Bioelectronics group

 

A lab dedicated to advancements in photoelectroceuticals and living bioelectronics

 

At the Tian Group, we blend physical chemistry with bioelectronics to forge drug‐free, cell‐based, and non‐genetic therapeutic strategies that pave the way for sustainable healthcare. By applying the principles of physical chemistry, we develop diverse electronics‐enabled biointerfaces that mimic cellular behaviors, harnessing both classical and quantum phenomena for precise, real‐time control of cellular electrophysiology. Our work has yielded advanced biophysical tools that offer unprecedented insight into subcellular processes without relying on conventional pharmacological methods.

We pioneered the concept of photoelectroceuticals and developed a range of platforms that enable the study of electrophysiology across multiple biological scales with high temporal resolution using optical methods. Since 2012, we have led advancements in living electronics, designing composite materials that not only integrate with biological systems but also adapt and respond like natural entities. Looking ahead, we are committed to shaping a future where our innovations drive breakthroughs in healing, environmental sustainability, and scientific exploration.

“When you are enthusiastic about what you do, you feel this positive energy. It’s very simple.”

Paulo Coelho, the author of “The Alchemist”

 

“The only metrics that will truly matter to my life are the individuals whom I have been able to help, one by one, to become better people.”

Clayton M. Christensen, in “How Will You Measure Your Life?”.

 

 

Group Highlights

Featured Lab Members

Changxu Sun has been exploring sustainable biointerface biomaterials and electronics, utilizing key components derived from fruit waste. Excitingly, his paper has just been accepted for publication in Matter!

Featured News

Jing Zhang’s wonderful work has been accepted by Nature Nanotechnology! Her research explores the effects of bioelectrical stimulation on intracellular granule formation and its innovative applications in regenerative medicine.

Featured Publications

In a recent episode of UChicago’s Big Brains podcast, Bozhi Tian shared his outlook on the future of bioelectronics, exploring its potential far beyond biomedical applications. He also spotlighted three publications from his lab—the optical cardiac pacemaker, living bioelectronics, and the antimicrobial patch!

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